W03 - Novel approaches in transpecies whole-brain network analysis (10:00-13:00)

Non-invasive mapping of brain functional activity provides key information to understand brain function and dysfunction at the individual level (personalized medicine). The development of novel functional imaging tools has emerged over the past years from functional magnetic resonance imaging (fMRI) to neuromodulatory tools. These, combined with the observation that large-scale neuronal networks tend to be conserved across species, offer stepping-stones to better understand the brain, and its pathological manifestations. This symposium will present novel methods used to elucidate mechanisms in clinical imaging, and means to enhance those with forward and back translations in animals. The symposium will gather established and rising stars in clinical and preclinical neuroimaging with the objective to inform the wider neuroscience community in the developments allowing for the better interpretation of functional connectivity markers used to study the healthy and diseased brain. The target audience is neuroscientists working with mammal models (physiology, animal behaviour), and/or applying neuroimaging tools in healthy and patient cohorts.

Moderators:
-Marine Célestine, Molecular Imaging Research Center, CEA, France
-Joanes Grandjean, Donders Institute for Brain, Cognition and Behaviour, Netherlands

Speakers:
-Chételat Gaël, Inserm U1077 PhIND, France – The role of functional connectivity in the propagation of lesions in Alzheimer’s Disease
-Christophe Bernard, Institut de Neurosciences des Systèmes, France – Controlling brain dynamics: from whole brain modelling to experimental validation in individuals
-Valerio Zerbi, ETH Zurich, Switzerland – Causal interplay between Locus Coeruleus and network dynamics using rodent fMRI combined with optogenetics and chemogenetics
-Madalena Fonseca, Wellcome Centre for Integrative Neuroimaging, UK – Functional MRI of large scale activity in behaving mice
-Marine Célestine, Molecular Imaging Research Center, CEA, France – Resting – State Functional MRI: processing and analysis in rodent
-Daniel Gutierrez, Italian Institute of Technology (IIT) – Center for Neuroscience and Cognitive Systems (CNCS), Italy –Evolutionarily conserved fMRI network dynamic principles in the mouse, macaque, and human brain